Assessment of the Risk of Developing COVID-19 in Patients with Connective Tissue Diseases of Shahid Beheshti Hospital of Kashan, Iran during 2020-21

Document Type : Original Article


1 Kashan University of Medical Sciences, Kashan, Iran

2 Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

3 Kashan University of Medical Sciences, Kashan, Iran.

4 Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

5 Kashan university of medical sciences



Objectives: Numerous investigations have been conducted thus far to explore the impact of COVID-19 on individuals with connective tissue diseases. The objective of this study was to assess both the risk and severity of COVID-19 in patients diagnosed with connective tissue disorders.
Methods: In this retrospective descriptive study, we conducted a review of the medical records of all patients with connective tissue disorders who were referred to the rheumatology clinic and Shahid Beheshti Hospital Kashan Iran between April 2020 and September 2021 and subsequently contracted COVID-19. The collected data related to connective tissue disease were analyzed using SPSS software, version 16.
Results: A total of 2370 patients with connective tissue diseases were included, out of which 190 cases (82.1% female) with a mean age of 50.98±14.37 years were diagnosed with COVID-19 (COVID-19 risk: 8.01%). The risk of COVID-19 was found to be 13.80% (142 out of 1030) in patients with inflammatory connective tissue disorders and 3.6% (48 out of 1340) in patients with non-inflammatory connective tissue disorders. A significant difference was observed between the inflammatory and non-inflammatory patient groups in terms of the severity of COVID-19 disease (p < 0.001), with inflammatory patients experiencing higher severity.
Conclusion: The findings of this study revealed COVID-19 disease exhibited greater severity in patients with inflammatory connective tissue disorders, and individuals with symptoms such as shortness of breath, lymphopenia, and severe lung CT scan findings had higher chances of hospitalization.


Main Subjects

Articles in Press, Accepted Manuscript
Available Online from 26 February 2024
  • Receive Date: 27 December 2023
  • Revise Date: 09 February 2024
  • Accept Date: 17 February 2024