Investigating the relationship between plasma D-dimer level and clinical outcome of COVID-19 patients admitted to Shahid Beheshti Hospital in Kashan in 2019

Document Type : Original Article


1 Department of Internal Medicine, School of Medicine

2 Department of Medical Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran

3 Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

4 Department of Vital Statistics and Epidemiology, School of Health, Kashan University of Medical Sciences, Kashan, Iran.

5 Department Pulmonary, Shahid Beheshti Hospital, Kashan, Iran.



Objectives: COVID-19 is a disease that affects multiple systems and is associated with abnormalities in blood coagulation. Among COVID-19 patients, it is common to observe elevated D-dimer levels alongside coagulation-related conditions, which may serve as potential indicators of more severe disease outcomes. Given the limited research on this topic, the current study aimed to explore the connection between plasma D-dimer levels and the clinical outcomes of individuals affected by COVID-19.
Methods: A retrospective cohort study was conducted, in which the medical records of COVID-19 patients admitted to Kashan's Shahid Beheshti Hospital in 2020 were retrospectively reviewed. The study collected data on demographic characteristics, vital signs, laboratory test results (including CRP, D-dimer, and ESR), and clinical outcomes. The collected data was analyzed using SPSS 22 software.
Results: Among the total of 240 patients, 36 individuals (15%) died after undergoing intubation. Significant differences were observed between the patients who recovered and those who died in terms of age, diabetes mellitus, hypertension, cardiovascular disease, diastolic blood pressure, respiratory rate, SPO2, CRP, ESR, D-dimer, and length of hospitalization (P < 0.05). The duration of hospitalization showed a significant and inverse association with SPO2, but not with D-dimer, ESR, or CRP (P < 0.05). Although D-dimer serum levels did not demonstrate a correlation with the length of hospitalization, they did exhibit a significant and inverse correlation with SPO2, as well as a significant and positive correlation with ESR and CRP (P < 0.05).
Conclusion: The levels of D-dimer in the serum of COVID-19 patients who require hospitalization are connected to patient outcomes, oxygen saturation (SPO2) levels, and the levels of inflammatory factors. Consequently, D-dimer levels can serve as useful prognostic indicators for COVID-19 patients.


Main Subjects

Articles in Press, Accepted Manuscript
Available Online from 26 February 2024
  • Receive Date: 27 October 2023
  • Revise Date: 13 February 2024
  • Accept Date: 17 February 2024