Acute Effect of Concurrent Exercise on Serum Leptin and Resistance Insulin Response in Sedentary Men

Document Type : Original Article


Department of Physical Education and Sport Sciences, Islamic Azad University, Mahallat Branch, Mahallat, Iran



This study aimed to determine the delayed effect of one session of concurrent exercise on serum leptin and resistance insulin levels of sedentary men.
Materials and Methods: 
Fifteen healthy young men with a mean age of 22.9 ± 1.7 years and a body mass index of 23.3 ± 1 kg/m2 voluntarily participated in this experimental research. They participated in one session of concurrent exercise including 20 min of aerobic running on a treadmill at 60%–70% maximum oxygen uptake plus a resistance exercise at the intensity of 70% of 1-repetition maximum with ten repetitions per set to second round. Blood serum leptin, glucose, insulin, and insulin resistance index were assessed before, 24, 48, and 72 h after the exercise program.
The results showed that leptin level did not change statistically significantly immediately and 72 h after the exercise termination (P > 0.05) but did decrease statistically significantly 24 and 48 h after the exercise program (P ≤ 0.05). The result also showed that insulin and insulin resistance levels decreased statistically significantly immediately after the exercise and lasted for up to 48 h postexercise (P ≤ 0.05); however, it returned to its initial value after 72 h of recovery (P > 0.05).
It was concluded that energy use in one session of concurrent exercise might reduce leptin levels up to 48 h of recovery. In addition, a decrease in insulin, a known inducer of leptin expression in adipocytes, occurs before the decrease in leptin. This change may mediate the decrease of leptin concentration.