The Prevalence of Latex Sensitivity among Operating Room Personnel: A Systematic Review and Meta‑Analysis

Document Type : Review


1 Master of Perioperative Nursing, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad,

2 Department of Operating Room, School of Nursing, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,

3 Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht,

4 Department of Occupational Health Engineering, School of Public Health, Kashan University of Medical Sciences, Kashan, Iran



Aims: Latex sensitivity has been a concern for health‑care workers in recent years. Due to the excessive exposure to latex products in the
operating room, the personnel of this department are exposed to high sensitivity to these products. Therefore, the present study was conducted to
investigate the prevalence of latex sensitivity among operating room personnel. Materials and Methods: This systematic review and meta‑analysis
conducted based on a Preferred Reporting Items for Systematic Reviews and Meta‑Analysis checklist. The present study researchers explored
four international databases, namely Medline/PubMed, ProQuest, Scopus, and Embase in February 2020. The selected keywords for international
databases were classified into three categories (a) operating room personnel, (b) latex sensitivity, and (c) prevalence. The collected data were entered
into the EndNote X8 software and analytical analysis was performed by STATA statistical software version 12. Results: Seventy‑five articles
were found by searching for databases. After several screening steps, 12 articles entered the final analysis. The results show that the prevalence of
latex sensitivity in total is 14.76 (confidence interval 95%: 9.27–20.25). Meta‑regression results showed that the relationship between the years
of study and the prevalence of latex sensitivity is not statistically significant (P = 0.222). Conclusion: The results of the present study showed
that sensitivity to latex is significantly prevalent among operating room staff. Due to the importance of sterility and sensitive working conditions
in the operating room, as well as frequent contact with latex products, it is important to pay attention to the side effects caused by latex powder.